BRICS report of 2016-2017: the distribution and antimicrobial resistance profile of clinical isolates from blood culture in China
10.3760/cma.j.issn.1674-2397.2020.01.011
- VernacularTitle:2016至2017年全国血流感染细菌耐药监测(BRICS)报告
- Author:
Yunbo CHEN
1
;
Jinru JI
;
Chaoqun YING
;
Peipei WANG
;
Qing YANG
;
Haishen KONG
;
Yongyun LIU
;
Ying HUANG
;
Yuanyuan DAI
;
Liping ZHANG
;
Hui DING
;
Liang GUO
;
Baohua ZHANG
;
Lisha ZHU
;
Haifeng MAO
;
Zhixiang LIAO
;
Yanhong LI
;
Lu WANG
;
Shuyan HU
;
Zhenghai YANG
;
Beiqing GU
;
Haixin DONG
;
Fei DU
;
Lin ZHENG
;
Bo QUAN
;
Wencheng ZHU
;
Jianzhong WANG
;
Lan MA
;
Rong XU
;
Li SUN
;
Aiyun LI
;
Junmin CAO
;
Jinhua LIANG
;
Hongyun XU
;
Kunpeng LIANG
;
Dengyan QIAO
;
Xiaoyan QI
;
Xiusan XIA
;
Lanjuan LI
;
Yonghong XIAO
Author Information
1. 浙江大学医学院附属第一医院 传染病诊治国家重点实验室，杭州 310003；感染性疾病诊治协同创新中心，杭州 310003
- From:
Chinese Journal of Clinical Infectious Diseases
2020;13(1):42-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution and antimicrobial resistance profile of clinical bacteria isolated from blood culture in China.Methods:The clinical bacterial strains isolated from blood culture from member hospitals of Blood Bacterial Resistant Investigation Collaborative System (BRICS) were collected during January 2016 to December 2017. Antibiotic susceptibility tests were conducted by agar dilution or broth dilution methods recommended by US Clinical and Laboratory Standards Institute (CLSI) 2019. WHONET 5.6 was used to analyze data.Results:During the study period, 8 154 bacterial strains were collected from 33 hospitals, of which 2 325 (28.5%) were Gram-positive bacteria and 5 829 (71.5%) were Gram-negative bacteria. The top 10 bacterial species were Escherichia coli (34.7%), Klebsiella pneumoniae (15.8%), Staphylococcus aureus (11.3%), coagulase-negative Staphylococci (7.4%), Acinetobacter baumannii (4.6%), Pseudomonas aeruginosa (3.9%), Enterococcus faecium (3.8%), Streptococci (2.9%), Enterobacter cloacae (2.7%) and Enterococcus faecalis (2.5%). Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus (MRCNS) accounted for 34.2%(315/922) and 77.7%(470/605), respectively. No vancomycin-resistant Staphylococcus was detected. The resistance rate of Enterococcus faecium to vancomycin was 0.6%(2/312), and no vancomycin-resistant Enterococcus faecium was detected. The ESBLs-producing rates in Escherichia coli, Klebsiella pneumoniae and Proteus were 55.7%(1 576/2 831), 29.9%(386/1 289) and 38.5%(15/39), respectively. The incidences of carbapenem-resistance in Escherichia coli, Klebsiella pneumoniae were 1.2%(33/2 831), 17.5%(226/1 289), respectively. The resistance rates of Acinetobacter baumannii to polymyxin and tigecycline were 14.8%(55/372) and 5.9%(22/372) respectively, and those of Pseudomonas aeruginosa to polymyxin and carbapenem were 1.3%(4/315) and 18.7%(59/315), respectively. Conclusion:The surveillance results from 2016 to 2017 showed that the main pathogens of blood stream infection in China were gram-negative bacteria, while Escherichia coli was the most common pathogen; the MRSA incidence was lower than other surveillance data in the same period in China; carbapenem-resistant Escherichia coli was at a low level during this surveillance, while carbapenem-resistant Klebsiella pneumoniae is on the rise.
