The correlation between hyperhomocysteinemia and hyperuricemia in the population undergoing physical examination
10.3760/cma.j.cn115624-20191015-0044
- VernacularTitle:体检人群中高同型半胱氨酸血症与高尿酸血症的相关性
- Author:
Wei ZHOU
1
;
Shaohui LIU
;
Fang LIU
;
Ying TAN
;
Meifang XIAO
;
Congfang LIU
;
Baoxiang WANG
Author Information
1. 中南大学湘雅医院健康管理中心，长沙 410008
- From:
Chinese Journal of Health Management
2020;14(4):386-390
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between hyperhomocysteinemia (HCA) and hyperuricemia (HUA).Methods:A total of 8 465 individuals who received a medical examination at the Xiangya Hospital Health Management Center of Central South University were selected as research subjects from January to June 2018. The multi-factor binary Logic regression method was adopted and four different models. The ratio ( OR) and its 95% trusted interval ( CI) between Hhcy group and normal control group were analyzed. Results:Compared to the normal control group, the OR(95% CI) of the probability of HUA in the Hhcy population was 3.272 (95% CI: 2.839 to 3.771, P<0.001) without correcting other factors; After correcting the influence of age and gender, the OR (95% CI) of the Hhcy population with HUA probability was 2.111 (95% CI: 1.811-2.461, P<0.001); After correcting age, gender, Body Mass Index (BMI), blood pressure, fasting blood sugar, triglycerin, low-density lipoprotein, and high-density lipoprotein, the OR(95% CI) of the Hhcy population with HUA probability was 2.163 (95% CI: 1.845 to 2.535, P<0.001); After correcting age, sex, BMI, blood pressure, fasting blood sugar, triglycerin, low-density lipoprotein, high-density lipoprotein, drinking, smoking, exercise time, and exercise intensity, the OR (95% CI) of the Hhcy population had a HUA probability of 2.209(95% CI: 1.845 to 2.646, P<0.001). Conclusion:The cross-sectional study confirmed that Hhcy was positively correlated with HUA. Reducing homocysteine levels may be a new approach to the health management of HUA.
