Comparison of 68Ga-PSMA PET/CT and 18F-FDG PET/CT in the diagnosis of biochemical recurrence of prostate cancer
10.3760/cma.j.cn321828-20200201-00032
- VernacularTitle:68Ga－PSMA－11 PET/CT与 18F－FDG PET/CT诊断前列腺癌生化复发的对比研究
- Author:
Yining WANG
1
;
Ruohua CHEN
;
Yumei CHEN
;
Jianjun LIU
Author Information
1. 上海交通大学医学院附属仁济医院核医学科 200127
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2020;40(8):470-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the diagnostic efficacy of 68Ga-prostate specific membrane antigen (PSMA)-11 PET/CT and 18F-flurodeoxyglucose (FDG) PET/CT in patients with prostate cancer biochemical recurrence after radical prostatectomy. Methods:A total of 82 patients ((76.7±7.1) years) with clinical diagnosis of biochemical recurrence after radical prostatectomy from June 2018 to August 2019 in Renji Hospital, School of Medicine, Shanghai Jiao Tong University were included. All patients underwent 68Ga-PSMA-11 PET/CT and 18F-FDG PET/CT within 2 weeks. The diagnostic efficacy of 2 methods were compared, and the detection rates were also compared among patients with different total prostate specific antigen (tPSA) levels (tPSA≤0.5 μg/L, 0.5 μg/L10.0 μg/L). Logistic regression analysis was applied to analyze the factors affecting the detection rate of 68Ga-PSMA-11 PET/CT. Results:A total of 57 patients (98 regional lesions) were detected by 68Ga-PSMA-11 PET/CT and/or 18F-FDG PET/CT. Patients were followed up for 2-12 months, and 50 patients (81 lesions) were found to have recurrence or metastasis of prostate cancer. The patient-related detection rate, sensitivity and positive predictive value of 68Ga-PSMA-11 PET/CT and 18F-FDG PET/CT were 68.29%(56/82) vs 36.59%(30/82), 96.00%(48/50) vs 52.00%(26/50), 85.71%(48/56) vs 86.67%(26/30); the detection rates were significantly different ( χ2=19.756, P<0.05). The patient-related detection rates of 68Ga-PSMA PET/CT were higher than those of 18F-FDG PET/CT under different tPSA levels, especially when 0.5 μg/L
