Study on tau related disease pattern of Alzheimer′s disease based on 18F-APN-1607 PET imaging
10.3760/cma.j.cn321828-20200205-00034
- VernacularTitle:基于 18F-APN-1607 PET影像的阿尔茨海默病tau蛋白沉积相关疾病模式探究
- Author:
Jianhao NING
1
;
Jiehui JIANG
;
Chunhua LIU
;
Weiqi BAO
;
Ming LI
;
Jiaying LU
;
Ling LI
;
Chuantao ZUO
;
Yihui GUAN
Author Information
1. 上海大学先进通信与数据科学研究院、特种光纤与光接入网教育部重点实验室 200444
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2020;40(4):213-218
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Exploring tau related disease pattern (tauRDP) in the brain of Alzheimer′s disease (AD) patients based on 18F-APN-1607 PET scan. Methods:18F-APN-1607 PET images were collected from 17 AD patients (6 males and 11 females, age: (61.7±12.3) years, Mini-Mental State Examination (MMSE) score: 17.6±7.9) and 10 normal controls (NC; 6 males and 4 females, age: (61.2±4.7) years) from Huashan Hospital of Fudan University. The scaled subprofile model (SSM) based on principal component analysis (PCA) technique was used to construct the tauRDP. Then the expression value of tauRDP in each sample was calculated. The differences on tauRDP expression values between AD patients and NC were compared by independent-sample t test. Pearson correlation analysis was used to analyze the correlation between tauRDP expression values and MMSE values in AD patients. Results:The tauRDP area mainly included: precentral gyrus, dorsolateral superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus of opercular part, inferior frontal gyrus of triangular part, supplementary motor area, medial superior frontal gyrus, left median cingulate and paracingulate gyri, right cuneus, superior occipital gyrus, middle occipital gyrus, postcentral gyrus, superior parietal gyrus inferior parietal, but supramarginal and angular gyri, supramarginal gyrus, angular gyrus, precuneus and middle temporal gyrus. There were significant differences ( t=4.395, P<0.001) between AD group (12.6±8.0) and NC group (0.0±1.0) in tauRDP expression values. The tauRDP expression values were correlated with MMSE values in AD group significantly ( r=-0.566, P=0.018). Conclusions:TauRDP established basing on SSM/PCA method can be used to quantitatively express the abnormal spatial distributions of tau deposition. Expression value of tauRDP has the potential to initially assess the severity of AD.
