Chemoattractant-mediated in situ tissue engineering for articular cartilage regeneration
10.3760/cma.j.cn121113-20200609-00374
- VernacularTitle:趋化剂介导的原位组织工程技术再生关节软骨的研究进展
- Author:
Zhen YANG
1
;
Hao LI
;
Fuyang CAO
;
Liwei FU
;
Cangjian GAO
;
Tianyuan ZHAO
;
Zhiguo YUAN
;
Yongjing DAI
;
Xiang SUI
;
Shuyun LIU
;
Quanyi GUO
Author Information
1. 中国人民解放军总医院第一医学中心骨科研究所、骨科再生医学北京市重点实验室、全军骨科战创伤重点实验室 100853；南开大学医学院，天津 300071
- From:
Chinese Journal of Orthopaedics
2020;40(17):1216-1226
- CountryChina
- Language:Chinese
-
Abstract:
The treatment of articular cartilage (AC) injury caused by various reasons is still a major clinical problem. The emergence of cartilage tissue engineering brings new hope for the treatment of AC injury. In general, AC tissue engineering can be divided into two categories, including cell-based tissue engineering and cell-free tissue engineering. Although cell-based tissue engineering can repair cartilage damage to a certain extent, existing therapeutic strategies still suffer from limited cell sources, high costs, risk of disease transmission, and complex procedures. However, the cell-free tissue engineering avoids these shortcomings and brings hope for in-situ AC regeneration. Non-cellular tissue engineering is mainly used to recruit endogenous stem cells/progenitor cells (SCPCs) to reach the site of cartilage injury, and provide a suitable regenerative microenvironment to promote cell proliferation and chondrogenic differentiation, then the maturation of new cartilage tissue was promoted. Therefore, it is also called as cell-homing in situ tissue engineering. Successful recruitment of endogenous SCPCs is the first step in in-situ cartilage tissue engineering. This review aims to introduce chemokine response of cartilage injury, systematically summarize traditional chemoattractant (chemokines and growth factors etc.) and emerging chemoattractant (functional peptides, exosomes and nucleic acid adapters etc.), evaluate the combination mode between chemoattractant and delivery devices, discuss the prospects and challenges of chemoattractant-mediated in situ tissue engineering and provide theoretical basis for the design of endogenous SCPCs homing-based in situ tissue engineering.
