Research progress in circular RNAs in spine and spinal cord diseases
10.3760/cma.j.cn121113-20200310-00146
- VernacularTitle:环状RNA在脊柱脊髓相关疾病中的作用研究进展
- Author:
Jianle WANG
1
;
Jun GAO
;
Yizhen HUANG
;
Gang LIU
;
Weiyu NI
;
Jianjun MA
;
Xiangqian FANG
;
Shuying SHEN
;
Shunwu FAN
Author Information
1. 浙江大学医学院附属邵逸夫医院骨科，杭州 310016；浙江省骨骼肌肉退变与再生修复转化研究重点实验室，杭州 310016
- From:
Chinese Journal of Orthopaedics
2020;40(11):743-748
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA (circRNA) is a kind of RNA with a circular structure. The unique structure of circRNA endows it with various cell biological functions and characteristics. It has become a research hotspot recently. CircRNA can play a role via mechanisms, such as microRNA (miRNA) sponge, RNA binding protein, peptide translation and regulation of gene transcription. CircRNA was found to be associated with disc degeneration, spinal cord injury, scoliosis, and facet arthritis. Some techniques, including bioinformatics and molecular biology techniques, microarray and high-throughput sequencing, can be used to predict and to discover disease-related circRNA, aiming to evaluate whether circRNA can be used as a molecular biomarker for spinal and spinal cord diseases. Based on the current role of circRNA, the corresponding therapeutic strategies have been carried out in experimental animals, which can provide theoretical basis for gene therapy. At present, the researches in circRNA for spinal and spinal cord diseases are still insufficient compared with those in other fields. Currently, the main direction focuses on the miRNA sponge mechanism of circRNA. Due to the variety of diseases in spinal surgery, the research progress of circRNA is also varied. In addition, the development of microarray and high-throughput sequencing technology have greatly promoted the researches in circRNA. The availability of public database is of great significance in the study. The present review summarized the current researches status of circRNA in spinal and spinal cord diseases, aiming to deepen understanding of circRNA in spinal and spinal cord diseases.
