Progress in clinical related research of Inflammatory factors and signaling pathways in lumbar degenerative diseases
10.3760/cma.j.cn121113-20190830-00368
- VernacularTitle:炎症因子及信号通路在腰椎退行性疾病中的研究进展
- Author:
Yifeng DA
1
;
Zhihao WANG
;
Wenkai ZHENG
;
Zhi HUANG
;
Wenlei WANG
;
Xuejun YANG
;
Jing TIAN
;
Yong ZHU
Author Information
1. 内蒙古医科大学第二附属医院胸腰脊柱外科，呼和浩特 010030
- From:
Chinese Journal of Orthopaedics
2020;40(9):597-606
- CountryChina
- Language:Chinese
-
Abstract:
Low back pain is becoming an important factor that affects people's quality of life today, and the social losses caused by lowback pain are hugeevery year. Lumbar disc herniation (LDH) is one of the main diseases that cause low back pain. The mechanism of lumbar disc herniation in the biomedical science is still controversial. Inflammatory factor is a cytokine secreted by tissue cells and involved in mediating the inflammatory response. Studies have shown that some factors stimulated by the extrusive nucleus pulposus, like inflammatory factors, degeneration-related genes and downstream expression products, can cause the degeneration of intervertebral disc. IL-1, IL-6, TNF-α, MMPs, and TGF-β have become the hot topicin disc degeneration. Signaling pathway is the main pathway for inflammatory factors to participate in the regulation of various biochemical reactions in cells. The inflammatory factors interact with different proteins to activate or inhibit different pathways, thereby achieving regulation of the cell cycle, regulates gene expression, induces immune inflammatory response, and apoptosis. Research on the role of various inflammatory factors in the body and related molecular signaling pathways will help us understand the mechanism of LDH. Most of the experimental studies only focus on the influence of a certain cytokine or single pathway on intervertebral disc degeneration, but different inflammatory factors and their signaling pathways often crosstalk with each other through special channels, forming a complex and precise signal transduction regulation network jointly regulates various physiological or pathological processes in the body, and the occurrence of disease is often accompanied by multiple factors. Studying the effect of a single signal network on the disease cannot fully explain the cause of the disease and related clinical manifestations. Therefore, clarifying the role of various inflammatory factors in IDD and exploring and analyzing the ways in which each factor regulates each other will provide ideas for understanding the mechanism of lumbar degeneration and exploring new methods for preventing and treating LDH in the future.
