Optimal preoperative timing of indocyanine green administration for laparoscopic cholecystectomy under fluorescence navigation
10.3760/cma.j.cn113884-20200113-00029
- VernacularTitle:荧光导航腹腔镜胆囊切除患者吲哚菁绿最佳术前注射时机分析
- Author:
Cong WANG
1
;
Shuodong WU
;
Chao LYU
;
Xiaoning WANG
;
Rui QIU
Author Information
1. 中国医科大学附属盛京医院第二普通外科，沈阳 110004
- From:
Chinese Journal of Hepatobiliary Surgery
2020;26(9):695-698
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the optimal preoperative timing of indocyanine green administration to do the fluorescence imaging during laparoscopic cholecystectomy.Methods:A total of 102 patients with laparoscopic cholecystectomy from January 2019 to November 2019 were retrospectively analyzed in this study, including 42 male patients and 60 female patients with an average age of 49(15-87) years old. The preoperative timing of indocyanine green (2.5 mg/ml, 1 ml) administration was set at 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, and 12 h before surgery, 12, 7, 8, 6, 6, 7, 8, 10, 8, 8, 8, 7, 7 patients, respectively. The intraoperative fluorescence imaging and signal contrast were compared.Results:Comparing with 0.5h group, the liver fluorescence intensities in 5, 6, 7, 8, 9, 10, 11 and12 h groups were significantly decreased (all P<0.05). There were no differences in the fluorescence intensities of the gallbladder, gallbladder duct, common bile duct and common liver duct between those groups with different injection timepoints (all P>0.05), and signal contrast was significantly lower in 0.5 h group than patients in 6, 7, 8, 9, 10, 11 and 12 h groups (all P<0.05). When preoperative timing of indocyanine green administration was 7 h, the fluorescence signal contrast reached the highest values of 0.29. Conclusions:The optimal preoperative timing of indocyanine green intravenous administration for laparoscopic cholecystectomy under fluorescence navigation was 7 h at dose 2.5 mg.
