Application value of hyperthermic intraperitoneal chemoperfusion in tumor recurrence after reptured and hemorrhage of hepatocellular carcinoma
10.3760/cma.j.cn113884-20191128-00391
- VernacularTitle:腹腔热灌注化疗在肝癌破裂出血术后肿瘤复发中的应用价值
- Author:
Yongzhu HE
1
;
Kun HE
;
Zeliang WANG
;
Ruiqin HUANG
;
Shaowei YE
;
Liwen LIU
;
Qijie LUO
;
Zeming HU
Author Information
1. 广东医科大学研究生院，广东湛江 524002
- From:
Chinese Journal of Hepatobiliary Surgery
2020;26(6):431-434
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the value hyperthermic intraperitoneal chemoperfusion after ruptured and hemorrhage of hepatocellular carcinoma.Methods:A retrospective study was conducted on 53 patients with ruptured hepatocellular carcinoma treated in Zhongshan Hospital Affiliated to Sun Yat-sen University from January 1, 2009 to January 1, 2019.Patients who underwent surgical resection combined with hyperthermic intraperitoneal chemoperfusion were included into the experimental group. Those who underwent surgical treatment only were included into the control group. The clinical data, postoperative hospital stay, complications, long-term tumor-free survival and overall survival were analyzed. Independent risk factors affecting prognosis were also determined.Results:Of the 33 patients in the experimental group, there were 27 males and 6 females, with a mean age ± s. d. being 50.49±11.59 years. There were 20 patients in the control group, including 17 males and 3 females, with a mean ± s. d. of 53.70±13.89 years. There were no significant differences in the length of postoperative hospital stay and complication rates between the two groups ( P>0.05). The tumor-free survival rate of the experimental group was significantly higher than that of the control group ( P<0.05). There was no significant difference in overall survival rates between the two groups ( P>0.05). Cox multivariate analysis showed that histological classification [ HR(95% CI): 27.700(1.695-452.794); 42.754(2.091-874.034)] and hyperthermic intraperitoneal chemoperfusion [ HR(95% CI): 0.238(0.086-0.661); 0.205(0.069-0.611)] were independent risk factors affecting tumor-free survival and overall survival (all P<0.05). Conclusion:Hyperthermic intraperitoneal chemoperfusion after surgical resection for ruptured hepatocellular carcinoma is a safe and effective treatment.
