Efficacy of intrahepatic cholangiocarcinoma treated with chemotherapy through portal vein pump after radical surgery
10.3760/cma.j.issn.1007-8118.2020.02.009
- VernacularTitle:肝内胆管癌患者术后门静脉泵化疗的效果
- Author:
Lianyuan TAO
1
;
Yadong DONG
;
Haibo YU
;
Kunfu DA
;
Jianhao MA
;
Gang JIA
;
Shundong CANG
;
Jianping CAI
;
Erwei XIAO
;
Deyu LI
Author Information
1. 河南省人民医院肝胆胰腺外科
- Keywords:
Bile duct neoplasms;
Intrahepatic cholangiocarcinoma;
Portal vein pump;
Prognosis;
Chemotherapy
- From:
Chinese Journal of Hepatobiliary Surgery
2020;26(2):124-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical application value of portal vein implantation pump for chemotherapy in patients with intrahepatic cholangiocarcinoma (ICC) after radical surgery.Methods The clinical data of 97 patients with ICC who underwent radical surgery in Henan People's Hospital from June 2012 to June 2016 were retrospectively analyzed.Results Among the 97 patients,14 patients received portal venous pump chemotherapy (portal group),33 patients received peripheral venous chemotherapy (peripheral group),and 50 patients did not receive postoperative chemotherapy (control group).There were no statistically significant differences in gender and age between the three groups.The results of survival analysis indicated that the disease-free survival (DFS) period and overall survival (OS) time in the portal group and the peripheral group were significantly better than that in control group (both P ＜ 0.05).In addition,despite the lack of statistical significance (P ＞ 0.05),for the control of intrahepatic metastasis,portal vein pump chemotherapy was better than that of systemic chemotherapy via peripheral vein,and almost all side effects of chemotherapy in the portal group were lower than those in the peripheral group.Conclusion Portal vein pump chemotherapy can improve the prognosis of intrahepatic bile duct patients,especially for the control of intrahepatic metastasis,and can reduce systemic side effects of chemotherapy.
