Research progress on radiotherapy-induced hippocampal damage and cognitive dysfunction in nasopharyngeal carcinoma

VernacularTitle:鼻咽癌放疗导致海马损伤及认知功能障碍研究进展
Author: Ling ZHOU ¹ ; Changjuan TAO ; Ming CHEN ; Zhonghua YU ; Yuanyuan CHEN
Author Information

1. 广东医科大学第一临床医学院，湛江　524000
From: Chinese Journal of Radiation Oncology 2020;29(11):1008-1011
CountryChina
Language:Chinese
Abstract: Radiation-induced cognitive dysfunction is a common complication in patients with nasopharyngeal carcinoma after undergoing radiotherapy, which has been proven to be associated with neurogenesis dysfunction, oligodendrocyte loss, vascular damage and abnormal cytokine expression. With the development of medicine, functional magnetic resonance image (fMRI) can detect the early lesions of cognitive dysfunction. Hippocampus-sparing technology and drug therapy (memantine, donepezil and bevacizumab) can mitigate radiation-induced cognitive dysfunction. In this article, the pathogenesis, neuroimaging, radiodosimetry and therapies of radiotherapy-induced cognitive dysfunction in nasopharynal carcinoma patients were reviewed.