1,5-Anhydroglucitol as a Marker of Glycemic Control.
- Author:
Soo Youn LEE
1
;
Seung Gyu LEE
;
Sun Young KONG
;
Sun Young KO
;
Jong Won KIM
Author Information
1. Department of Clinical Pathology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea. suddenbz@samsung.co.kr
- Publication Type:Original Article
- Keywords:
1,5-Anhydroglucitol(1,5-AG);
Diabetes;
Renal failure
- MeSH:
Blood Glucose;
Creatinine;
Fructosamine;
Gas Chromatography-Mass Spectrometry;
Glucose;
Humans;
Hyperglycemia;
Kidney Failure, Chronic;
Plasma;
Renal Insufficiency
- From:Korean Journal of Clinical Pathology
2000;20(2):157-162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: 1,5-Anhydroglucitol(1,5-AG) has shown to be a better indicator for current status of glycemia than HbA1c or fructosamine. The concentration of 1,5-AG is stable because of large storage pool and metabolic inertness, little influenced by assay variation with broad range of values. Since its reabsorption is competitively inhibited by glucosuria, plasma 1,5-AG decreases with increasing hyperglycemia in diabetic patients. But impairment of renal function may also affect its concentration. We introduced 1,5-AG as a new marker of glycemic control and evaluated the clinical usefulness and the effect of renal function. METHODS: We assayed plasma concentration of 1,5-AG using gas chromatography mass spectrometry in 36 healthy controls, 39 diabetic patients with normal renal function, 19 nondiabetic patients with chronic renal failure. We examined the relationship bewteen 1,5-AG and HbA1c or glucose. Correlation between 1,5-AG and serum creatinine was also investigated. RESULTS: 1,5-AG concentrations were significantly reduced in diabetic patients and in patients with chronic renal failure, compared to healthy controls. 1,5-AG had negative correlation with plasma glucose and HbA1c in healthy controls and diabetic patients with normal renal function, but not in patients with chronic renal failure. The value of 1,5-AG varies wider than that of HbA1c. CONCLUSIONS: 1,5-AG showed close correlation with glucose and HbA1c and detected subtle changes in glycemia. Therefore, measurement of 1,5-AG would be useful in monitoring glycemic control in diabetic patients with normal renal fucntion. But it would be inappropriate to use 1,5-AG for the evaluation of glycemic control in patients with renal failure.
