Early screening of high-risk patients with radiation-induced hypothyroidism in nasopharyngeal carcinoma by hematological examination

Ling Zhou; Chaonan Zhu; Jia Chen; Shuang Huang; Changjuan Tao; Wei Shen; Ming Chen; Zhonghua YU; Yuanyuan Chen

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Early screening of high-risk patients with radiation-induced hypothyroidism in nasopharyngeal carcinoma by hematological examination

VernacularTitle:血液学检查可早期筛查鼻咽癌放射性甲状腺功能减退高危患者
Author: Ling ZHOU ¹ ; Chaonan ZHU ; Jia CHEN ; Shuang HUANG ; Changjuan TAO ; Wei SHEN ; Ming CHEN ; Zhonghua YU ; Yuanyuan CHEN
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1. 广东医科大学第一临床医学院，湛江　524000
From: Chinese Journal of Radiation Oncology 2020;29(9):739-743
CountryChina
Language:Chinese
Abstract: Objective:To analyze the relationship between hematological examination combined with clinical factors and radiation-induced hypothyroidism (HT) in patients with nasopharyngeal carcinoma (NPC).Methods:Clinical data of 206 patients with NPC who received radiotherapy in Cancer Hospital of University of Chinese Academy of Sciences between January 2015 to August 2018 were retrospectively analyzed. The correlation between general clinical data, hematological examination and HT was analyzed to establish a hematological prediction model.Results:Univariate analysis showed that sex, N-stage, thyroid volume, average dose, V 20Gy, V 25Gy, V 30Gy, V 35Gy, V 40Gy, V 45Gy, fibrinogen content, cholinesterase and neutrophil count were closely associated with the incidence of HT. Multivariate analysis showed that thyroid volume, fibrinogen content and cholinesterase were the independent predictors of HT. Conclusion:The combination of sex, N-stage, thyroid volume, dose parameters, fibrinogen content, cholinesterase, neutrophil percentage and neutrophil count can predict the incidence of HT (AUC=0.777).