Relationship between adjuvant radiotherapy dose and pathologic complete response in patients with locally advanced esophageal squamous cell cancer
10.3760/cma.j.cn113030-20200301-00082
- VernacularTitle:局部晚期食管鳞癌新辅助放疗剂量与病理完全缓解关系分析
- Author:
Xiaoxiao ZENG
1
;
Hongna SUN
;
Hao WEI
;
Yong XU
;
Xiaojuan ZHOU
;
Zhenyu DING
;
Youling GONG
;
Jin WANG
;
Lin ZHOU
;
You LU
;
Yong YUAN
;
Yang HU
;
Yongmei LIU
Author Information
1. 四川大学华西医院胸部肿瘤科，成都 610041；四川省简阳市人民医院肿瘤科二 641400
- From:
Chinese Journal of Radiation Oncology
2020;29(8):644-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the dose of preoperative neoadjuvant radiotherapy and the pathologic complete response (pCR) rate in patients with locally advanced squamous cell esophageal cancer (ESCC).Methods:Clinical data of 116 patients with ESCC who received neoadjuvant chemoradiotherapy followed by esophagectomy in our cancer center from July 2017 to December 2019 were retrospectively analyzed. The radiation doses were divided into 2 ranges based on Grays (Gy) received: 40-45 Gy and 45 Gy or more.Results:The overall pCR rate was 38. 8%(45/116). pCR was observed in 35 out of 80(44%) patients treated with 40-45 Gy and 10 of 36(28%) patients treated with 45 Gy or more. The pCR rate did not significantly differ between two groups [(40-45 Gy) vs.( ≥ 45 Gy), P=0.105)]. Conclusions:Preoperative neoadjuvant radiotherapy with a higher dose (≥ 45 Gy) fails to increase the pCR rate in patients with locally advanced ESCC. Prospective randomized trials are required to determine the optimal dose of preoperative adjuvant radiotherapy.
