Advances in immunoregulation and mechanism of heavy ion beam radiotherapy
10.3760/cma.j.issn.0254-5098.2020.11.014
- VernacularTitle:重离子束肿瘤放疗的免疫调节作用和机制研究进展
- Author:
Jiangtao WANG
1
;
Quanlin GUAN
;
Juntao RAN
Author Information
1. 兰州大学第一医院放疗科 兰州大学第一临床医学院 730000
- From:
Chinese Journal of Radiological Medicine and Protection
2020;40(11):888-892
- CountryChina
- Language:Chinese
-
Abstract:
Heavy ion radiation has significant radiological and biological advantages over conventional radiation. While directly killing tumor cells, heavy ion beam can reduce immune escape and promote the initiation and activation of effector T cells by inducing immunogenic death of tumor cells, regulating tumor phenotype, enhancing antigen formulation, and changing tumor microenvironment to regulate the immune response. This article will review the immunomodulatory effect of heavy ion beam and the molecular mechanisms associated with immune checkpoint inhibitor therapy.
