Analysis of prognostic factors affecting brainstem glioma
10.3760/cma.j.issn.0254-5098.2020.08.006
- VernacularTitle:影响脑干胶质瘤的预后因素分析
- Author:
Shaoqing LIU
1
;
Baomin ZHENG
;
Shaowen XIAO
;
Xiaolong XU
;
Dan ZHAO
;
Weixin LIU
;
Weihu WANG
;
Yan SUN
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科 恶性肿瘤发病机制及转化研究教育部重点实验室 100142（现在承德市中心医院放化疗中心 067000）
- From:
Chinese Journal of Radiological Medicine and Protection
2020;40(8):606-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore overall survival(OS) and prognostic factors of brainstem gliomas (BSG) after intensity modulated radiotherapy (IMRT) by a retrospective single-center analysis.Methods:A total of twenty-one patients with BSG were collected in the Department of Radiation Oncology, Peking University Cancer Hospital from January 2012 to September 2019. All patients underwent IMRT. OS and potential prognostic factors were analyzed, including gender, age, operation type, imaging classification, tumor location, WHO grade, chemotherapy, radiotherapy pattern, time interval between morbidity and the first treatment, and radiation dose.Results:Eighteen of twenty-one patients were followed up more than 3 months. The median follow-up time was 15.5 (5.3-25.6) months. The median overall survival (mOS) was 20 (14.1-25.8) months. The 1 and 2-year OS rates were 86.2% and 34.5% respectively. Operation type, imaging classification, tumor location, WHO grade and radiotherapy pattern were the prognosis factors ( χ2=4.829-20.261, P<0.05). Conclusions:Patients with maximal safe surgical resection, focal endogenesis / exogenesis, tumor located in mesencephalon, low-grade gliomas and/or received postoperative radiotherapy have a better prognosis. It has certain reference value for guiding the clinical practice.
