Influence of histone modification on cell radiosensitivity
10.3760/cma.j.issn.0254-5098.2020.07.013
- VernacularTitle:组蛋白修饰影响细胞辐射敏感性的研究进展
- Author:
Yuchuan ZHOU
1
;
Chunlin SHAO
Author Information
1. 复旦大学放射医学研究所，上海 200032
- From:
Chinese Journal of Radiological Medicine and Protection
2020;40(7):559-563
- CountryChina
- Language:Chinese
-
Abstract:
Histone modification plays an important role in the process of cellular DNA damage repair. In recent years, a great number of studies have shown that histone modification affectsradiation responses including recruitment of DNA damage repair factors, creation of chromatin open structures and establishment of repressive histone marks.Regulation of histone modification may influence the process of DNA damage repair and thus affect radiation sensitivity. In this paper, the effects of histone modification on DNA damage repair, cellular radiosensitivity and the underlying mechanisms are reviewed.
