Comparison of the treatment outcomes between video-assisted thoracoscopic lobectomy and stereotactic body radiotherapy for early-stage non-small cell lung cancer
10.3760/cma.j.issn.0254-5098.2020.06.005
- VernacularTitle:胸腔镜肺叶切除术与立体定向放疗治疗早期非小细胞肺癌的疗效比较
- Author:
Kun QIAN
1
;
Baiqiang DONG
;
Fangxiao LU
;
Ming CHEN
;
Jianping CAO
Author Information
1. 苏州大学医学部放射医学与防护学院 放射医学与辐射防护国家重点实验室 江苏省放射医学协同创新中心 江苏省放射医学与防护重点实验室 215123
- From:
Chinese Journal of Radiological Medicine and Protection
2020;40(6):439-445
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To make comparisons of treatment outcomes between video-assisted thoracoscopic surgery (VATS) lobectomy and stereotactic body radiotherapy (SBRT) for early stage non-small cell lung cancer (NSCLC).Methods:Overall survival (OS), cancer specific survival (CSS), locoregional control (LRC), and disease-free survival (DFS) were retrospectively compared between early stage NSCLC patients who underwent VATS lobectomy and SBRT at our institution from January 2012 to December 2016. Propensity score matching (PSM) was carried out to reduce selection bias between two groups based on age, gender, Karnofsky performance score (KPS), Charlson comorbidity index (CCI), pulmonary function, and tumor diameter.Results:A total of 567 patients treated with VATS lobectomy ( n=458) or SBRT ( n=109) were included. 104 patients were matched for further analysis (52 in VATS lobectomy group and 52 in SBRT group). The median follow-up time was 44 months. the 3- and 5-year OS were 94.2% and 91.6% for VATS lobectomy and 88.6% and 79.9% for SBRT ( P=0.097), respectively. No statistically significant differences were noted in 5-year CSS (91.6% vs. 83.7%, P=0.270). The cumulative incidence of LRC was comparable between two group (94.0% and 85.9% vs. 93.5% and 93.5% at 3, 5 years, P=0.621). Differences in the DFS were not statistically significant (80.5% and 79.0% at 5 years, P=0.624). In the VATS lobectomy group, 10% patients ( n=5) experienced ≥ grade 3 CTCAE toxicity. One patient died of septicemia due to severe lung infection within 30 d after VATS lobectomy. In the SBRT group, one patient suffered from grade 3 radiation pneumonitis. There were no grade 4 or 5 toxicities in SBRT group. Conclusions:This propensity matched analysis suggests that SBRT can be an alternative option to VATS lobectomy for stage I-II NSCLC. Randomized trials are needed to evaluate the outcomes.
