Investigation on the levels of interleukins and TGF-β1 in the population in natural high background area
10.3760/cma.j.issn.0254-5098.2020.05.004
- VernacularTitle:天然高本底地区人群白介素水平及转化生长因子β1水平调查
- Author:
Ying TANG
1
;
Shibiao SU
;
Yali JIN
;
Haihui LIN
;
Cuiju WEN
;
Weijun TAN
Author Information
1. 广东药科大学公共卫生学院，广州 510310（现在广东省职业病防治院评价所，广州 510300）
- From:
Chinese Journal of Radiological Medicine and Protection
2020;40(5):349-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of long-term low dose ionizing radiation on the levels of interleukin (IL) and TGF-β1 in the population in high background radiation area(HBRA).Methods:Appropriate amount of peripheral blood was drawn from 41 and 44 healthy men aged 45-65 years who were randomly selected from Tangkou town of Yangjiang city (HBRA) and Hengpo town of Enping city (control area, CA), respectively. After centrifugation and stratification, the upper plasma of blood was separated to determine IL-2, sIL-2R, IL-4, IL-5 and TGF-β1 by using ELISA. The difference of plasma IL of the residents in those two regions was analyzed. The influence of region, age, smoking, drinking and income on the indexes of ILs and TGF-β1 was evaluated by Covariance analysis.Results:The concentration of IL-2 at HBRA area was slightly higher than those in the control area, but the other indexes were lower than those in CA residents. The differences of IL-5 ( t=7.124, P<0.001) and TGF-β1 ( t=4.900, P<0.001) between two areas were significant statistically. Covariance analysis showed that smoking had a significant effect on IL-2 level ( F=5.283, P<0.05). Conclusions:Under the influence of long-term low-dose ionizing radiation, all kinds of plasma interleukin levels of residents in HBRA were different with that in CA. The immune balance was biased towards Th1 type cytokines, and the immune function in HBRA was slightly stronger than that in CA, suggesting that long-term chronic low-dose ionizing radiation may induce adaptive changes in the immune function, which needs further study.
