Cytogenetic analysis of the victim followed-up at 4 year after 192Ir radiation accident in Nanjing
10.3760/cma.j.issn.0254-5098.2020.03.005
- VernacularTitle:南京 192Ir放射事故患者照后第4年细胞遗传学随访
- Author:
Xue LU
1
;
Hua ZHAO
;
Jin WANG
;
Shuang LI
;
Xuelei TIAN
;
Furu WANG
;
Mei TIAN
;
Ningle YU
;
Qingjie LIU
Author Information
1. 中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室 世界卫生组织辐射防护与健康合作中心，北京 100088
- From:
Chinese Journal of Radiological Medicine and Protection
2020;40(3):183-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To screen the indicators of retrospective dose estimation, based on 5 cytogenetic methods to assess the victim followed-up at 4 year after 192Ir radiation accident in Nanjing. Methods:The chromosome aberration (dic + r) assay, cytokinesis block micronucleus (MN) and nucleoplasmic bridge (NPB) assay, fluorescence in situ hybridization (FISH)-based and G banding-based translocation analysis were used to retrospective biological dose estimation. Results:The estimated doses of FISH-based and G banding -based analysis were 1.45 and 1.21 Gy respectively, which was similar to the biological dose estimated short time after the accident. However, the estimated doses by chromosome aberration, micronucleus and nucleoplasmic bridge method were 0.56, 0.45 and 0.41 Gy respectively, which were lower than the corresponding biodose. Correction factors were used to adjust the biodose.Conclusions:In the 4th years after exposure, the estimated biological doses by FISH-based and G banding-based translocation were consistent with the biodose.Therefore, the two methods were suitable for retrospective dose estimation, while correction factors should be considered in chromosome aberration method for retrospective dose estimation.
