A case-control study on clinical characteristics, awareness of foods & drinks and compliance of 111 early-onset gout cases
10.3760/cma.j.cn141217-20191106-00382
- VernacularTitle:早发痛风111例临床特点与饮食饮品认知度及用药依从性的病例对照研究
- Author:
Yuchen DUAN
1
;
Cibo HUANG
;
Suyan CAO
;
Yanhong HUANG
;
Kuanting WANG
;
Ping ZENG
;
Yalun DAI
;
Ming GAO
;
Yongjing CHENG
;
Min FENG
;
Like ZHAO
;
Fang WANG
;
Aihua LIU
;
Yingjuan CHEN
;
Yingjue DU
;
Chunmei ZHANG
;
Xing ZHOU
;
Qian WANG
;
Jia HUANG
;
Ming YANG
Author Information
1. 北京医院风湿免疫科国家老年医学中心 100730
- From:
Chinese Journal of Rheumatology
2020;24(5):328-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical characteristics and compliance of early-onset gout patients by case-control analysis.Methods:A total of 111 early-onset patients (onset age ≤35 years old) were included as Group A, and 111 non-early-onset patients (onset age >35 years old) with matched disease durationwere included as Group B. The differences ofclinical characteristics, causes of acute gout attack, dairy diet habits, compliance, and misunderstanding of the disease were compared.Results:Compared with the non-early-onsetgoutpatients, the early-onset patients had a higher proportion of obesity (63 cases vs 28 cases), family history (36 cases vs 20 cases) and tophus (39 cases vs 23 cases) and higher level of VAS scores (8.5±1.3 vs 7.6±1.7; χ2=22.988, P<0.01; χ2=5.749, P=0.016; χ2=5.729, P=0.017; t=4.639, P<0.01), lowerproportionof the first metatarsophalangeal joint involvement as the initial joint involvement (45.9%, 51 cases vs 59.4%, 66 cases; χ2=4.066, P=0.044), higher proportion of the ankle involvement as the initial joint involvement (34.2%, 38 cases vs 21.6%, 24 cases; χ2=4.386, P=0.036), higher proportion of alcohol drinkers and high fructose drinkers, which was more likely to relate to alcohol intake, strenuous exercise and high fructose intakeas trigger of the flare ( χ2=6.513, P=0.011; χ2=7.126, P=0.008; χ2=1.978, P=0.160), while the proportion of regular exercisers and on diet in the family was lower ( χ2=22.887, P<0.01; t=-4.917, P<0.01). The proportion of poor diet and medication compliance in Group A was higher than that in Group B(57.7%, 64 cases vs 38.7%, 43 cases; χ2=5.207, P=0.022; χ2=5.867, P=0.015). As for the reason for poor treatment compliance, early-onset gout patients were more worry about the side-effects of drugs than non-early onset patients ( χ2=4.190, P=0.041). There was no significant difference between the two groups in the main misunderstanding of gout. Conclusion:Although early onset gout patients are young, their condition is more serious, and compliance is poorer, this group of patients should be highly valued in clinical diagnosis and treatment.
