Z-score reference ranges of normal fetal middle cerebral artery peak systolic velocity
10.3760/cma.j.cn131148-20200218-00082
- VernacularTitle:胎儿大脑中动脉收缩期峰值流速Z-评分正常范围的研究
- Author:
Xinyan LI
1
;
Caiying PANG
;
Huan HUANG
;
Chunyan ZHANG
;
Fangtao WEI
;
Xiaoxian TIAN
;
Huiyun HU
Author Information
1. 广西壮族自治区妇幼保健院超声科 广西胎儿疾病临床研究中心 广西壮族自治区出生缺陷预防控制研究所，南宁 530003
- From:
Chinese Journal of Ultrasonography
2020;29(7):592-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To construct Z-score ranges for normal fetal middle cerebral artery peak systolic velocity(MCA-PSV).Methods:From May 2017 to October 2019, 865 normal singleton fetuses of 10th to 40th gestational weeks underwent prenatal ultrasound in the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region. Using fetal biometric parameters as independent variables, and measurement of MCA-PSV on standard section as dependent variables, the regression analyses of the mean(M) and the standard deviation(SD) for each parameter were calculated separately and then the best fitting equation was selected. A group of diseases which might cause the abnormal MCA-PSV were assessed using these standards.Results:①Strong correlations were found between MCA-PSV and fetal biometric parameters ( r=0.935-0.939, P<0.001). ②Quadratic or cubic regression equations were fitted to the models of the means of the MCA-PSV, whereas linear equations were fitted to the SDs. ③In these case groups, intrauterine growth restriction, severe preeclampsia, intrauterine infection and homozygous α-thalassemia-1 demonstrated Z-score>2 reflective of increased MCA-PSV with varying degrees, especially with the homozygous α-thalassemia-1 fetus being the most significant (17/20, 85%). Conclusions:The calculation of Z-score for MCA-PSV as a function of fetal biometric parameters is intuitive and simple, it can be used as an important indicator especially for homozygous α-thalassemia-1.
