Assessment of left ventricular dysfunction of sarcomere mutation carriers in hypertrophic cardiomyopathy by three-dimensional speckle tracking imaging combined with conventional echocardiography
10.3760/cma.j.issn.1004-4477.2020.02.002
- VernacularTitle:三维斑点追踪技术联合常规超声心动图评价肥厚型心肌病肌小节突变携带者左心室功能的早期改变
- Author:
Juan ZHANG
1
;
Jing WANG
;
Xiaoli ZHU
;
Bo WANG
;
Qianli YANG
;
Jing LI
;
Jun ZHANG
;
Liwen LIU
Author Information
1. 空军军医大学西京医院超声医学科 空军军医大学西京医院肥厚型心肌病诊治中心 陕西省肥厚型心肌病多学科诊治与会诊中心，西安 710032
- From:
Chinese Journal of Ultrasonography
2020;29(2):104-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of three-dimensional speckle tracking imaging (3D-STI) and conventional echocardiography in evaluating left ventricular function characteristics of sarcomere mutation carriers in hypertrophic cardiomyopathy.Methods:Totally 91 subjects with sarcomere mutations in family HCM but without left ventricular hypertrophy (G + /P - group), and 100 normal family members with gender and age matched as the control group (G -/P - group) were enrolled from the center of hypertrophic cardiomyopathy of Xijing Hospital affiliated to the Air Force Military Medical University from February 2013 to April 2017. They all received the comprehensive evaluation of 3D-STI and conventional echocardiography. The ultrasonic paramaters between the two groups were compared. And the diagnostic performance of these paramaters with sarcomere mutations was evaluated. Results:Compared with the G -/P - group, the G + /P -group had larger left atrial diameter (LAD), longer left ventricular isovolumic relaxation time (IVRT), reduced mitral annular systolic velocity (e′), elevated E/e′ ratio, as well as impaired left ventricular global longitudinal and radial strain(GLS and GRS) ( P<0.05). Moreover, the GLS≤19.9%(AUC 0.861, sensitivity 61.4%, specificity 98.5%) and IVRT≥75.5 ms(AUC 0.762, sensitivity 61.4%, specificity 72.6%) showed the best diagnostic performance with sarcomere mutations ( P<0.05). Conclusions:In HCM family members, the sarcomere mutations carriers without left ventricular hypertrophy exhibit impaired left ventricular diastolic function, reduced longitudinal and radial systolic function.Moreover, the GLS and IVRT show the best diagnostic performance for those with sarcomere mutations.
