3D bioprinting and its application in cartilage repair
10.3760/cma.j.cn115530-20200717-00473
- VernacularTitle:生物3D打印及其在软骨修复中的应用
- Author:
Hanbo WANG
1
;
Tao LI
;
Jinwu WANG
Author Information
1. 济宁医学院基础医学院 272000
- From:
Chinese Journal of Orthopaedic Trauma
2020;22(9):783-787
- CountryChina
- Language:Chinese
-
Abstract:
With developing economy and improving living standards, more and more sports injuries occur, particularly articular cartilage wear. Once cartilage is injured, its self-repair ability is much weak because it lacks nerve, lymphatic duct, or blood supply. Compared with traditional 3D printing, biological 3D printing can realize a high density loading of various seed cells in different spatial distributions and construction of complex active microenvironments. In treatment of bone and cartilage defects, 3D bioprinting can not only make up for a limited source of autogenous cartilage and bone but also solve problems in personalized shaping and insufficiency of biological activity of artificial cartilage and bone. This paper summarizes the latest research progress in China and abroad, concerning current common 3D bioprinters with different printing principles, biological seed cells and bio-inks. We especially introduce the bio-inks for cartilage tissue engineering, the fused deposition forming (FDM) techniques and biological tissue bioreactors in cartilage tissue engineering. We also foresee their development and future research trends in 3D bioprinting in cartilage, hoping our information may help the research in cartilage tissue engineering and its clinical translation.
