Effect of type H endothelial cells on the coupling of angiogenesis and osteogenesis
10.3760/cma.j.cn115530-20191008-00344
- VernacularTitle:H型内皮细胞在成血管-成骨偶联中的作用
- Author:
Feng WANG
1
;
Jia XU
;
Lingchi KONG
;
Qinglin KANG
Author Information
1. 上海交通大学附属第六人民医院骨科 200233
- From:
Chinese Journal of Orthopaedic Trauma
2020;22(7):641-644
- CountryChina
- Language:Chinese
-
Abstract:
Type H endothelial cells (CD31 hiEMCN hi), a special subtype of vascular endothelial cells, are distributed mainly in endosteum and long bone metaphysis. They recruit and activate osteoprogenitor cells and promote endochondral ossification through paracrine, thereby promoting osteogenesis. On the contrary, their biological activities can be regulated by osteoclasts and osteoblasts. At the same time, the mutual regulation of type H endothelial cells is also closely related to the process of angiogenesis and osteogenesis. This article reviews the characteristics and cytokine expression profiles and the mediating role in mutual regulation of angiogenesis and osteogenesis of the cells, offering an insight for establishment of a bone regeneration strategy based on the coupling of angiogenesis and osteogenesis.
