Research progress in pathogenesis of neurologic heterotopic ossification
10.3760/cma.j.issn.1001-8050.2020.09.015
- VernacularTitle:神经源性异位骨化发病机制的研究进展
- Author:
Yijun LIU
1
;
Yuhui KOU
;
Dianying ZHANG
;
Baoguo JIANG
Author Information
1. 北京大学人民医院创伤骨科，创伤与神经再生研究所 100044
- From:
Chinese Journal of Trauma
2020;36(9):853-858
- CountryChina
- Language:Chinese
-
Abstract:
Neurologic heterotopic ossification (NHO) is a pathological phenomenon that involves the formation of ectopic bone in soft tissues, which is associated with central nervous system injury. NHO may cause severe complications such as disorder of limb's activity, severe pain, and skin ulcer. The pathogenesis of NHO is not clear. In the past decades, there's better understanding of NHO pathogenesis, and potential predictive and therapeutic targets were found. The authors overview the NHO pathogenesis based on osteogenic factors, osteogenic precursor cells and microenvironments, soas to provide references for clinical diagnosis and treatment.
