Research progress in molecular mechanism of blast lung injury
10.3760/cma.j.issn.1001-8050.2020.08.014
- VernacularTitle:肺爆震伤的分子机制研究进展
- Author:
Hong WANG
1
;
Junhong GAO
;
Wenjuan ZHANG
;
Jinren LIU
;
Xiaolin FAN
;
Cunzhi LI
;
Qing LU
;
Qingbo KONG
;
Airong QIAN
Author Information
1. 西北工业大学生命学院，西安 710072；兵器工业卫生研究所，西安 710065
- From:
Chinese Journal of Trauma
2020;36(8):749-754
- CountryChina
- Language:Chinese
-
Abstract:
Lung is one of the most sensitive target organs of human beings under the shock waves. Due to its serious injury, rapid development and high mortality, blast lung injury has been a widely concerned research topic in the field of military medicine. In the normal physiological state, the body is in a dynamic balance between pro-inflammaton and anti-inflammation, oxidation and anti-oxidation, promoting apoptosis and inhibiting apoptosis. While blast lung injury breaks the balance and causes physiological, biochemical and pathological changes in the body, seriously leading to acute respiratory distress syndrome and multiple organ dysfunction syndrome, and eventually the mortality. So far, the researches on blast lung injury mainly involve damage model, pathogenesis, pathological changes, intervention treatment and so on, which has achieved great research findings. In the review, the authors summarize the progress of molecular mechanism for blast lung injury from the perspective of inflammatory reaction, oxidative stress, apoptosis and so on, which may promote the discovery of new targets for the diagnosis, treatment and rehabilitation intervention of blast lung injury.
