Clinical Study for The Ovarian Malignancy Under the Age of Twenty Years Old.
- Author:
Kee Don KIM
;
Jung Han LEE
;
Kyung Taek MIN
;
Young Jin MOON
;
Kyoung Tai KIM
;
Sam Hyun CHO
;
Youn Yeung HWANG
;
Ho Jun LIM
;
Hang LEE
- Publication Type:Original Article
- Keywords:
Ovarian malignancy;
Young women;
Germ cell tumor
- MeSH:
Bleomycin;
Chemotherapy, Adjuvant;
Cystadenocarcinoma, Mucinous;
Drug Therapy;
Drug Therapy, Combination;
Endodermal Sinus Tumor;
Etoposide;
Female;
Fertility;
Follow-Up Studies;
Gynecology;
Humans;
Incidence;
Medical Records;
Mucins;
Neoplasms, Germ Cell and Embryonal;
Obstetrics;
Ovarian Neoplasms;
Pregnancy Rate;
Retrospective Studies;
Teratoma
- From:Korean Journal of Obstetrics and Gynecology
1999;42(2):363-368
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The purpose of this study was to review the incidence, types, chemotherapy regimens, operation methods, pregnancy rate and propiosis of the ov#arian malignancy under the age of twenty years old. METHODS: Retrospective reviews of the medical recordings for 22 patients with ovarian malignancy under the age of twenty years old in the Department of Obstetrics and Gynecology, Hanyang University from 1986 to 1997 were done. RESULTS: Gerin cell tumor accounts for the majority of cases (77%), whereas 5 patients(23%) belong to the common epithelial poup which were all mucinous type. Our experiences with 22 cases are as followings: 5 mucinous cystadenocarcinoma, 8 immature teratoma, 4 endodermal sinus tumor, 3 dysgernma and 2 mixed germ cell tumor. The incidence of this group was 8.2% (22/266) in all ovarian malignancy. Fourteen of them are stage I, each one is, stage II and IV, and six patients are stage III. The average age was 14.9 years old in germ cell tumor and 18.4 yems old in mucinous cystadenoearcinoma. Malignant ovarian cancer under the age of twenty can be treated with conservative surgery, followed by adjuvant chemotherapy. Commonly used chemotherapeutic regimens were VAC(Vincristine, Actinomycin-D; Cyclophosphamide), VBP(Vinblastine, Bleomycin, Cisplatin) and BEP(Bleomycin, Etoposide, Cisplatin). Second look operations were done in 11 patienth and histologic positive findings were detected in 4 of them. The length of follow-up ranged ftom 3 months to 137 months and median value was 44 rnonths. CONCLUSIONS: It is concluded that for young women who wish to preserve child-bearing capacity, regardless of the stage of the tumor, fertility preserving surgery with complete surgical staging, if necessary followed by combination chemotherapy is an appropriate treatment.
