Point Mutations in a Mitochondrial Transfer RiboNucleic Acid Gene in South Korean Women with Preeclampsia.
- Author:
Ill Woon JI
;
Hak Soon KIM
;
Kap Soon JU
- Publication Type:Original Article
- Keywords:
Preeclampsia;
South Korean;
Mitochondrial transfer ribonucleic acid mutations
- MeSH:
DNA;
DNA Restriction Enzymes;
Female;
Humans;
Point Mutation*;
Polymerase Chain Reaction;
Pre-Eclampsia*;
RNA*;
Wills
- From:Korean Journal of Obstetrics and Gynecology
1999;42(2):377-381
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was performed to find out mitochondrial deoxyribonucleic acid mutations in preeclampsia because Mendelian models fail to explain all the patterns of inheritance in preeclampsia. METHODS: Ten preeclampsia patients and two of their related family members who have the obstetric history of preeclampsia were studied. The mitochondrial transfer ribonucleic acidleu[UUR] gene was amplified using polymerase chain reaction, cut by a restriction endonuclease (Apa , and also sequenced to see the whole gene. RESULTS: There were neither the known mutation at Nucleotide 3243 nor other mutations on the mitochondrial transfer ribonucleic acidleu[UUR] gene in these objects. CONCLUSION: It seems that the known mutation of mitochondrial transfer ribonucleic acidleu[UUR] gene is not so frequently detected in preeclampsia of South Korean, But it could not be concluded how many South Korean women with preeclampsia have the mutation.
