Research progress in mechanism and preclinical treatment for blast traumatic brain injury
10.3760/cma.j.issn.1001-8050.2020.05.014
- VernacularTitle:脑冲击伤致伤机制和临床前治疗的研究进展
- Author:
Yushou WU
1
;
Jiake CHAI
Author Information
1. 解放军总医院第四医学中心全军烧伤研究所，北京 100037
- From:
Chinese Journal of Trauma
2020;36(5):470-474
- CountryChina
- Language:Chinese
-
Abstract:
Blast traumatic brain injury (bTBI) often causes irreversible damage to the brain which seriously endangers the lives of the wounded and can be accompanied by various complications, and has high disability and morbility in peacetime and wartime. The bTBI is divided into primary injury and secondary injury, resulting in a series of neuropsychiatric symptoms. The mechanism of bTBI contains cracking effect, implosion effect, inertia effect and cavitation effect. Multiple factors, such as shrapnel injury caused by explosion, collision of body being thrown with hard objects and smash of buildings, can lead to brain injury. There are challenges in the diagnosis and treatment of bTBI, because the injury is often closed, the onset is slow, the diagnosis is easy to missed, the pathogenesis is complex, and the clinical manifestations vary. The authors review the mechanism of bTBI and its preclinical treatment, hoping to provide a way for the preclinical treatment of bTBI.
