Levels of Insulin - like Growth Factor 1 ( IGF - 1 ) , Insulin - like Growth Factor Binding Protein 3 ( IGFBP - 3 ) , Osteocalcin and Deoxypyridinoline biochemical markers in either surgical menopause or natural menopause women.
- Author:
Soo Yong CHOUGH
;
Se Kyu KIM
;
Jae Kwan LEE
- Publication Type:Original Article
- Keywords:
IGF-1;
IGFBP-3;
Osteocalcin;
Deoxypyridinoline;
Menopause
- MeSH:
Biomarkers*;
Carrier Proteins*;
Female;
Humans;
Insulin*;
Insulin-Like Growth Factor Binding Protein 3;
Insulin-Like Growth Factor Binding Proteins*;
Insulin-Like Growth Factor I;
Menopause*;
Osteocalcin*;
Plasma;
Radioimmunoassay
- From:Korean Journal of Obstetrics and Gynecology
1999;42(2):382-387
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The purpose of this study was to investigate possible menopause related changes in circulating insulin-like growth factor binding protein 3 (IGFBP-3) levels and their relationship with insulin-like growth factor 1 (IGF-1) plasma levels, osteocalcin(Ost) and urinary deoxypyridinoline(Dpd) in either surgical menopause or natural menopause, METHOD: Seventy-two postmenopausal women (surgical menopause 48, natural menopause 24) were invited to participate in this study. In all subjects plasma IGF-1 and IGFBP-3 levels were measSURED by radioimmunoassay and Ost and Dpd were measured by enzyme linked immunosorbent assay(ELISA). RESULTS: No difference was found between mean IGFBP-3 plasma levels in the two groups studied(3,522 +/- 926 vs 3,854 +/- 569 ng/ml), while mean IGF-1 levels were significantly lower in natural menopause as compared with surgical menopause (natural 126 +/- 44 vs surgical 163 +/- 66 ng/ml, p=0.007). No difference was found between mean Ost levels in the two groups studied (natural menopause 8.0 +/- 2.9 vs surgical menopause 8,9 +/- 2.1 ng/ml, p=0.113) and mean Dpd levels in the two studied (natural menopause 6.8 +/- 2.3 vs surgical menopause 7.8 +/- 3.4 mM, p=0.213). CONCLUSION: IGF-1 was significantly lower in natural menopause as compared with surgical menopause, but no significant difference was found in IGFBP-3, Ost, and Dpd levels
