Research progress in mechanism of icariin regulating osteoclast differentiation for treatment of osteoporosis
10.3760/cma.j.issn.1001-8050.2020.04.017
- VernacularTitle:淫羊藿苷调控破骨细胞分化治疗骨质疏松症的机制研究进展
- Author:
Youhan WANG
1
;
Lingbo KONG
;
Baorong HE
Author Information
1. 陕西中医药大学，咸阳 712046
- From:
Chinese Journal of Trauma
2020;36(4):377-382
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a type of chronic disease characterized by increased bone fragility caused by destruction of bone microstructure and high risk of vertebral compression fractures. Previous researches show hyperactive bone resorption caused by abnormal activity of osteoclasts is highly related to osteoporosis. Icariin, a traditional Chinese medicine monomer, has been reported to have a biological effect in regulating osteoclast signaling pathway RANK/RANKL/OPG. It also can participate in the regulation of multiple stages of osteoclast differentiation. These results suggest icariin has an important role in regulating osteoclast differentiation and bone erosion. The authors systematically review the related researches on the mechanism of icariin in regulating osteoclast differentiation, in order to provide new ideas for osteoporosis-targeted treatment for osteoporosis.
