Research progress of mesenchymal stem cells in the treatment of osteoarthritis
10.3760/cma.j.cn121361-20191221-00060
- VernacularTitle:间充质干细胞在骨关节炎治疗中的研究进展
- Author:
Yishuang CUI
1
;
Zhenquan LAI
;
Ming LAI
;
Qijia LI
;
Qian WANG
Author Information
1. 华北理工大学基础医学院，河北省唐山市 063000
- From:
Clinical Medicine of China
2020;36(6):568-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Osteoarthritis is a degenerative disease with slow progress, which is caused by aging, obesity, trauma and other factors.It has a great impact on the daily life of middle-aged and elderly patients.Compared with traditional drug, protein and antibody therapies, stem cells are expected to radically change the medical treatment of osteoarthritis, because they have the ability to replace and repair tissues and organs such as osteoarthritis and joints, and have better homology and lower immune rejection.In different types of stem cells, mesenchymal stem cells originate from the mesoderm and can differentiate into different cells to form organs originating from the mesoderm lineage.In view of its ability to differentiate into other types of cells, MSCs have also been used to treat tissues and organs of ectodermal and endodermal lineages such as diabetes mellitus and Parkinson's disease.Whether MSCs can differentiate into lineages other than mesoderm lineages and the efficacy of treating organ diseases of ectoderm and endoderm lineages have been debated.This review will discuss the clinical features of osteoarthritis, the developmental origin and differentiation potential of MSCs, and the role of MSCs and scaffolds in the treatment of osteoarthritis.
