Effect of interleukin6 on the malignant progression of ovarian cancer
10.3760/cma.j.issn.1008-6315.2020.02.018
- VernacularTitle:白细胞介素6对卵巢癌恶性演进的影响
- Author:
Tongshuo ZHANG
1
;
Ziyue ZHANG
;
Weixin LI
;
Xiaoqin GUO
Author Information
1. 武警后勤学院病原生物学教研室，天津 300309
- From:
Clinical Medicine of China
2020;36(2):177-180
- CountryChina
- Language:Chinese
-
Abstract:
Modern oncology believes that tumor-associated inflammation is one of the prominent features of tumor microenvironment.The occurrence and development of ovarian cancer is inseparable from the influence of inflammatory factors in the microenvironment.Interleukin-6 (IL-6) is an important pro-inflammatory factor that regulates tumor cell growth.Current studies found that the expression of IL-6 and IL-6 receptor both increase in patients with ovarian cancer, which are closely related to poor clinical prognosis.The mechanism of effect of IL-6 on the malignant progression of ovarian cancer has been a research hotspots in the field of tumor microenvironment.In combination of the research results of this group in recent years, we mainly review the role of IL-6 in ovarian cancer including proliferation, invasion and metastasis, blood system disorders and drug resistance.Then, we introduce the research frontiers and application prospects of IL-6 targeted therapy for ovary cancer.
