Clinical analysis of 35 cases of drug-induced hypersensitivity syndrome
10.3760/cma.j.cn431274-20200601-00707
- VernacularTitle:药物超敏反应综合征35例临床分析
- Author:
Xiufang CHEN
1
;
Yujia LIANG
;
Chunhai TU
;
Pan CHEN
;
Jianping XIE
;
Rong XIAO
;
Guiying ZHANG
;
Yi ZHAN
Author Information
1. 长沙市中心医院皮肤性病科 410007
- From:
Journal of Chinese Physician
2020;22(10):1478-1482
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features of drug-induced hypersensitivity syndrome (DiHS) and enhance the recognition of its diagnosis and treatment.Methods:Drug-induced hypersensitivity syndrome diagnosed in the Second Xiangya Hospital of Central South University in recent 6 years were retrospectively analyzed and summarized.Results:Of 35 cases of drug-induced hypersensitivity syndrome there were ten types of suspected drugs. Antibiotics were the most common allergy-inducing drug, followed by allopurinol, antiepileptics, and non-steroidal anti-inflammatory drugs. The expected clinical findings of DiHS were characterized by skin rash, fever, enlarged lymph nodes, which may be accompanied by eosinophilia, liver function damaged. The lesions of DiHS were variable and the majority of cases 65.71%(23/35) were characterized by eruptive papules.The main therapeutic approach of DiHS was systemic application of glucocorticoids and intravenous immunoglobulin (IVIG). When necessary its combination with immunosuppressant or hemoperfusion (HP).Conclusions:DiHS should be on the high alert when a patient with medication history, rash, high fever and lymph nodes large, accompanied by eosinophilia, liver function damaged. Predictors of good prognosis are early diagnosis and treatment.
