Differences of clinical features between smokers and non-smokers with chronic obstructive pulmonary disease
10.3760/cma.j.cn431274-20200901-01213
- VernacularTitle:吸烟与非吸烟慢性阻塞性肺疾病患者的临床特征差异
- Author:
Jiaxi DUAN
1
;
Zhi XIANG
;
Xin LI
;
Wei CHENG
;
Yuqin ZENG
;
Yan CHEN
;
Shan CAI
;
Hong LUO
;
Ping CHEN
Author Information
1. 中南大学湘雅二医院呼吸与危重症医学科；中南大学呼吸疾病研究所，长沙 410011
- From:
Journal of Chinese Physician
2020;22(10):1452-1456
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical differences between smokers and non-smokers with chronic obstructive pulmonary disease (COPD).Methods:The clinical data of 5 183 COPD patients, including 3 688 smoking COPD patients and 1 495 non-smoking patients, were collected from the respiratory and critical medicine clinics of 12 Grade-A hospitals in Hunan Province and Guangxi Zhuang Autonomous Prefecture from December 2016 to December 2019. The general condition, clinical symptoms, acute exacerbation history and pulmonary function of the two groups were compared.Results:⑴ Non-smokers were more likely to be female, to be younger and had a lower educational level ( P<0.05). There was no difference of body mass index (BMI) and marriage statue between two groups ( P>0.05). ⑵ Clinical features: the incidence of chest distress in non-smoking COPD patients was higher than that in smoking COPD patients (86.8% and 81.4%, respectively), and the incidence of asthma was also higher than that of smoking COPD patients (86.0% and 83.1%, respectively), with statistically significant difference ( P<0.05). There was no significant difference in the incidence of cough and expectoration between the two groups ( P>0.05). The COPD assessment test (CAT) score of non-smoking COPD patients was significantly higher than that of smoking group (16.2±6.4) and (15.7± 6.5) ( P<0.05). There was no significant difference in the score of dyspnea modified medical research council dyspnea scale (mMRC) and the risk of acute exacerbation between the two groups ( P>0.05). The first second exertional volume as a percentage of predicted value (FEV 1%) and forced vital capacity (FVC) of non-smoking COPD patients were higher than those of smoking COPD patients ( P<0.05). Conclusions:Compared to smokers with COPD, non-smokers more are more likely to be female and have more severe clinical symptoms.
