The value of ABVS in evaluating the response of neoadjuvant chemotherapy for different molecular subtypes of breast cancer
10.3760/cma.j.cn431274-20190501-00513
- VernacularTitle:ABVS对不同分子亚型乳腺癌新辅助化疗疗效的评估价值
- Author:
Nan ZHOU
1
;
Hongqiao ZENG
;
Shouhong LIU
;
Huan TANG
;
Xiyun QUAN
Author Information
1. 中南大学湘雅医学院附属株洲医院超声科 412000
- From:
Journal of Chinese Physician
2020;22(9):1342-1346
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of Automated Breast Volume Scanner (ABVS) in evaluating the response of neoadjuvant chemotherapy(NACT) for different molecular subtypes of breast cancer.Methods:Based on immunohistochemical technique, breast cancer was divided into three molecular subtypes according to the negative or positive results of estrogen receptor (ER), progesterone receptor (PR) and proto oncogene human epidermal growth factor receptor 2 (HER2), namely luminal group [ER(+ ) or PR(+ ), and HER2(-/+ )], triple-negative group [ER(-), PR(-) and HER2(-)], HER2 group [ER(-), PR(-)and HER2(+ )]. ABVS was used to analyze the changes of tumor size related parameters in 78 breast cancer patients with three subtypes during NACT.Results:After NACT, the size , area and volume of primary lesion diminished obviously ( P<0.05). 19 cases achieved complete response and 40 cases achieved partial response according to response evaluation criteria in solid tumors (RECIST). After the end of the second cycle of NACT, the primary tumor shrank significantly in HER2 group, and luminal and tri-negative groups were significantly reduced after the end of the third cycle. Conclusions:ABVS has a good value in evaluating the efficacy for different molecular substypes of NACT in breast cancer.
