Effect of intraoperative autologous blood transfusion on coagulation function and inflammation after cesarean section
10.3760/cma.j.cn431274-20190711-00821
- VernacularTitle:术中自体血液回输对剖宫产产妇术后凝血功能及炎症反应的影响
- Author:
Jianyin YIN
1
;
Aiyuan LI
;
Liang CHEN
Author Information
1. 湖南省妇幼保健院麻醉科，长沙 410008
- From:
Journal of Chinese Physician
2020;22(8):1153-1156
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of intraoperative autologous blood transfusion on coagulation function and inflammatory reaction after cesarean section.Methods:By retrospective analysis, 114 parturients who underwent caesarean section in our hospital from March 2017 to February 2019 with intraoperative blood transfusion were selected and divided into autologous group (57 cases) and allogeneic group (57 cases) according to the source of intraoperative blood transfusion. The changes of coagulation markers and inflammatory reaction indexes were detected and recorded respectively before and 3 days after operation, respectively. And the complications after blood transfusion were compared between the two groups.Results:On the 3rd day after operation, the expression of P65 gene and the optical density of P65 in both groups increased significantly, but the autogenous group was lower than the allogeneic group ( P<0.01); the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6 and IL-1β in both groups increased significantly, but the autogenous group was lower than the allogeneic group ( P<0.01); the D-dimer (D-D), thrombomodulin (TM), tissue plasminogen activator (t-PA) and fibrinolytic-antifibrinolytic complex (PAP) in both groups were slightly higher than those before operation, and the data between the two groups also changed, but with no statistical significance ( P>0.05). In addition, the incidence of complications in the autogenous group was 5.26%(3/57), which was significantly lower than that in the allogeneic group (17.54%, 10/57) (χ 2=4.25, P=0.04). Conclusions:Autologous blood transfusion has no significant effect on the coagulation function of parturients during cesarean section, but compared with allogeneic blood transfusion, autologous blood transfusion can effectively reduce the inflammatory reaction of parturients after operation, and has a significant effect on reducing the occurrence of complications after operation, which is conducive to improving the prognosis.
