Relationship between neutrophil / lymphocyte ratio, cystatin C and microvascular complications in type 2 diabetes mellitus
10.3760/cma.j.cn431274-20190723-00871
- VernacularTitle:中性粒细胞/淋巴细胞比值及胱抑素C与2型糖尿病微血管并发症的关系
- Author:
Fang ZHOU
1
;
Le ZHANG
;
Xiaodan ZHAI
;
Cong LIU
Author Information
1. 中国医科大学附属盛京医院内分泌科，沈阳 110022
- From:
Journal of Chinese Physician
2020;22(8):1168-1171
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between neutrophil / lymphocyte ratio (NLR) and cystatin C (Cys-C) and microvascular complications in type 2 diabetes mellitus.Methods:1 990 patients with type 2 diabetes mellitus were divided into simple diabetes group (N group), simple diabetic retinopathy group (DR group), simple diabetic nephropathy group (DN group) and diabetic retinopathy combined with diabetic nephropathy group (DRN group). The general data and biochemical indexes were collected to analyze the differences of NLR and Cys-C among the groups. The risk factors of diabetic microvascular complications were analyzed by multivariate logistic regression.Results:The NLR in DRN group was higher than that in N group and DN group ( P<0.05), but there was no difference between DRN group and DR group ( P>0.05). The serum Cys-C in DRN group was higher than that in N group, DN group and DR group, with statistical significance ( P<0.05). After adjusting for age, duration of diabetes and other factors, multivariate logistic regression showed that NLR was an independent risk factor for type 2 diabetic retinopathy complicated with diabetic nephropathy, while serum Cys-C was not. Subgroup analysis showed that NLR was an independent risk factor for both diabetic retinopathy and diabetic nephropathy, while Cys-C was only related to diabetic nephropathy, which was not related to retinopathy ( P<0.05). Conclusions:NLR is associated with type 2 diabetic retinopathy and diabetic nephropathy, while serum Cys-C is only associated with type 2 diabetic nephropathy, but not with diabetic retinopathy.
