Preventive use of antiemetic drugs on the incidence of nausea and vomiting after cesarean section under multi-mode analgesia
10.3760/cma.j.cn431274-20200628-00875
- VernacularTitle:预防性使用止吐药物对多模式镇痛下剖宫产术后恶心呕吐发生的影响
- Author:
Yin GU
1
;
Pan GU
;
Xuebing XU
Author Information
1. 香港大学深圳医院麻醉科 518053
- From:
Journal of Chinese Physician
2020;22(7):977-980,985
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of preventive use of antiemetic drugs on postoperative nausea and vomiting (PONV) in patients with cesarean section(CS) under multi-mode analgesia.Methods:The clinical data of 5530 patients with cesarean section in the University of Hong Kong-Shenzhen Hospital (HKU-SZH) from February 1, 2016 to January 31, 2020 were retrospectively collected and divided into four groups: Ondansetron 4 mg group (group A, n=2 712), Dexamethasone 5 mg group (group B, n=39), Ondansetron 4 mg combined with Dexamethasone 5 mg group (Group C, n=413), and blank group (Group D, n=2 366). All drugs were given before the end of theoperation. The prophylactic effectiveness with different antiemetic prescription has been compared in this study. Results:There were no significant differences in height, weight, age, the ratio of NRs≥6 at 24 h and oxycodone usage among the four groups ( P>0.05). The incidence of postoperative nausea and vomiting was 2.29%(62/2 712), 0(0/39), 1.45%(6/413) and 1.90%(45/2 366), respectively. There was no significant difference between the four groups ( P=0.463). Conclusions:Prophylaxis antiemetic administration seems do not reduce the incidence of PONV after CS under this strategy of multi-mode analgesia.
