Effect of thyroid stimulating hormone level and thyroid peroxidase antibody status on pregnancy outcome in early pregnancy
10.3760/cma.j.cn431274-20200214-00138
- VernacularTitle:妊娠早期促甲状腺激素水平及甲状腺过氧化物酶抗体状态对妊娠结局的影响
- Author:
Shuping WANG
1
;
Xin LIU
;
Weibo WANG
;
Zhenjing WANG
;
Kui LIU
;
Na LYU
Author Information
1. 山东省东营市人民医院内分泌科 257091
- From:
Journal of Chinese Physician
2020;22(7):1053-1059
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between thyroid stimulating hormone (TSH) level and thyroid peroxidase antibody (TPOAb) status in the first trimester on pregnancy outcomes.Methods:A total of 2 095 pregnant women with complete clinical data from department of pregnancy endocrinology or department of obstetrics in Dongying People′s Hospital from January 1, 2018 to November 31, 2019.According to the TSH level detected before 12 + 6 weeks of gestation, all pregnant women were divided into normal TSH (0.1 μIU/ml≤TSH< 2.5 μIU/ml), high TSH (2.5 μIU/ml≤TSH≤4.0 μIU/ml), sub-clinical hypothyroidism during gestation (4.0 μIU/ml0.05). Multivariate logistic regression analysis of gestational diabetes mellitus and preterm delivery showed that the risk of gestational diabetes mellitus was significantly increased in group F compared with the control group. Age, gestational status, and TPOAb positivity were risk factors for gestational diabetes. The risk of premature birth in group D, group E and group F was higher than that in the control group [odds ratio ( OR)>1]. Age and TPOAb positivity were risk factors for preterm delivery in pregnant women ( OR>1, P<0.05). Conclusions:TPOAb positive in early pregnancy combined with subclinical hypothyroidism in pregnancy will increase the risk of gestational diabetes, while TPOAb positive in early pregnancy combined with TSH on the high side or subclinical hypothyroidism in pregnancy will increase the risk of premature delivery, so the management of such pregnant women should be strengthened and active treatment should be given if necessary.
