Research progress on the mechanism of aggressive behavior induced by antiepileptic drugs
10.3760/cma.j.cn431274-20190403-00384
- VernacularTitle:抗癫痫药物诱发攻击行为机制的研究进展
- Author:
Hongling HOU
1
;
Xinjiang ZHANG
;
Lihong TAO
;
Guoxian SUN
Author Information
1. 扬州大学附属医院神经内科 225001
- From:
Journal of Chinese Physician
2020;22(7):1109-1115
- CountryChina
- Language:Chinese
-
Abstract:
Antiepileptic drugs (AEDs) are the main treatments of epilepsy, but their use is usually limited by adverse reactions, among them psychiatric and behavioral ones including aggressive behavior. Levetiracetam , perampanel, and topiramate , which have diverse mechanisms of action, have been associated with aggressive behavior. 5-HT and γ-aminobutyric acid (GABA), especially glutamate [via α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptor (AMPA) receptor] seem to play key roles. Other mechanisms involve hormones, epigenetics and alternative psychosis. Neurological and/or mental health disorders tend to increase aggressive behavior sensitivity. The adverse reactions caused by AEDs are getting more and more attention. Clinicians may identify and manage this side effect as early as possible, if the risk factors and underlying mechanisms of aggressive behavior induced by antiepileptic we find. This article will explain the possible mechanisms.
