Effect of clotrimazole vaginal tablets combined with lactobacillus vaginal capsules on inflammation and oxidative stress in pregnant women with candidal vaginitis
10.3760/cma.j.cn431274-20190303-00197
- VernacularTitle:克霉唑阴道片联合乳酸杆菌阴道胶囊对妊娠合并念珠菌性阴道炎患者的疗效
- Author:
Min PENG
1
;
Qiong LUO
;
Ling ZHANG
Author Information
1. 四川省广元市中心医院妇产科 628000
- From:
Journal of Chinese Physician
2020;22(6):871-874
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The effect of clotrimazole vaginal tablets combined with lactobacilli vaginal capsules on inflammatory response and oxidative stress in pregnant patients with candidal vaginitis.Methods:A prospective study of 126 patients with candidal vaginitis was randomly divided into control group and observation group, 63 cases in each group. The control group received clotrimazole vaginal tablets and the observation group received clotrimazole vaginal tablets combined with lactobacillus vaginal capsule treatment. The efficacy, inflammatory factor levels, oxidative stress and pregnancy outcomes of the two groups were observed.Results:The total clinical effective rate of the observation group was significantly higher than that of the control group (95.24% vs 80.95%, P<0.05). After treatment, the levels of tumor necrosis factor α, interleukin-6, and C-reactive protein inflammatory factors in the observation group were lower than those in the control group. The levels of superoxide dismutase and nitric oxide in the observation group were higher than those in the control group ( P<0.05), and the levels of malondialdehyde and plasma endothelin-1 were lower than those in the control group ( P<0.05). The incidence of premature delivery and premature rupture of membranes in the observation group was significantly lower than that in the control group ( P<0.05). Conclusions:Clotrimazole vaginal tablets combined with lactobacillus vaginal capsules for the treatment of pregnancy with candida vaginitis are effective and can reduce vaginal inflammation, improve oxidative stress, and reduce the occurrence of adverse pregnancy outcomes such as premature delivery and premature rupture of membranes.
