Effect of group B streptococcus infection on pregnancy outcome and neonate prognosis in the late stage of pregnancy
10.3760/cma.j.cn431274-20200212-00120
- VernacularTitle:妊娠晚期孕妇感染B族链球菌对母婴结局的影响
- Author:
Songyun HAN
1
;
Wenying MENG
;
Xiaoqing LI
Author Information
1. 北京市通州区妇幼保健院妇产科 101100
- From:
Journal of Chinese Physician
2020;22(5):718-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the pregnancy outcome and neonates prognosis in the late pregnant women with or without group B streptococcus (GBS) infection, and the women with or without standard treatment for GBS, so as to provide scientific evidence for improving the maternal and infant prognosis.Methods:From July 2018 to June 2019, women in the late stage of pregnancy who came to Tongzhou Maternal & Child Health Hospital of Beijing for prenatal examination were selected in our study. Questionnaire survey and GBS sampling test were conducted. They were divided into two groups based on the result of GBS positive or negative, and women with GBS infection were further divided two groups whether they accepted standard treatment for GBS or not. All of them were followed up to observe and record the situation of pregnancy outcome and neonates prognosis.Results:1 127 women completed the GBS test and follow-up in this study with an average age of (26.5±4.8)years old and a mean gestation of (36.6±0.9)weeks. Of them, 142 women were tested for GBS positive, and the rate of GBS infection was 12.6%. 104 women (73.2%) accepted the standard treatment for GBS. The incidence of puerperium infection (4.9% vs 0.9%, P=0.001), neonatal infection (2.1% vs 0.1%, P=0.003), neonatal asphyxia (2.8% vs 0.5%, P=0.017), amniotic fluid pollution (4.2% vs 1.1%, P=0.013) in the GBS positive group were significantly higher than those of the GBS negative group. Furthermore, the incidence of puerperium infection (13.2% vs 1.9%, P=0.021) and amniotic fluid pollution (15.8% vs 0, P<0.001) in the group with out GBS standard treatment were significantly higher than the group with GBS standard treatment. Conclusions:GBS infection in the late stage of pregnancy can significantly increase the incidence of infection, and the outcome for pregnant women and infant may be worse if they do not accept standard treatment. Therefore, GBS screening for pregnant women in the late stage of pregnancy and early effective treatment are very essential to improve the maternal and infant prognosis.
