The functions and mechanisms of BLACAT1 in malignant tumors
10.3760/cma.j.cn431274-20190401-00375
- VernacularTitle:膀胱癌相关转录因子1在恶性肿瘤中的作用及机制
- Author:
Shuwan XU
1
;
Haoming XIA
;
Zewei GAO
;
Rongju HUANG
;
Enyu TANG
;
Xingming JIANG
Author Information
1. 哈尔滨医科大学附属第二医院普通外科 150086
- From:
Journal of Chinese Physician
2020;22(3):469-473
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs (lncRNAs) are a kind of transcripts which are longer than 200nt and have not protein-coding ability due to the lack of an open reading frame. However, lncRNAs can be involved in tumorigenesis and progression in various ways at the transcriptional and post-transcriptional levels. Bladder cancer associated transcript 1 (BLACAT1) as a lncRNA located on human chromosome 1q32.1, is ectopic expression in various tumors (bladder cancer, gastric malignant tumor, lung carcinoma, et al) and can regulate tumor cell proliferation, anti-apoptosis, invasion and metastasis by different mechanisms leading to occurrence and development of tumors. In this review, we summarized current studies of the functions and mechanisms of BLACAT1 in malignant tumors.
