Value of ultrasound combined with serum CA125, CA199 and CEA in the differential diagnosis of ovarian benign and malignant tumors
10.3760/cma.j.issn.1008-1372.2020.02.020
- VernacularTitle:超声联合血清CA125、CA199、CEA检测在卵巢良恶性肿瘤鉴别诊断中的价值
- Author:
Wan ZHOU
1
;
Heng ZHANG
;
Geping ZHANG
;
Cuirong BAI
Author Information
1. 陕西省铜川矿务局中心医院超声科 727000
- Keywords:
Ultrasonography;
CA125;
CA199;
Carcinoembryonic antigen;
Ovarian neoplasms
- From:
Journal of Chinese Physician
2020;22(2):245-248,253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic values of ultrasonography combined with serum cancer antigen 125 (CA125),serum carbohydrate antigen 199 (CA199),serum carcinoembryonic antigen (CEA) in ovarian malignant tumors.Methods From November 2015 to December 2017,140 patients with ovarian cancer admitted to the hospital were selected as subjects,and ultrasound examination was carried out with IU22 ultrasound diagnostic instrument.The patients were divided into 92 cases of benign ovarian tumors and 4-8 cases of malignant ovarian tumors through pathological diagnosis.The serum CA125,CA199 and CEA of all patients were detected by automatic biochemical analyzer,and receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of four combined detection in ovarian malignancies.Results The coincidence rate of ultrasound diagnosis in ovarian benign tumor patients was significantly higher than that in ovarian cancer patients (P ＜ 0.05).The levels of serum CA125,CA199 and CEA in benign ovarian tumors were significantly lower than those in malignant ovarian tumors (P ＜0.05),and the levels of serum CA125,CA199 and CEA in patients with stage Ⅰ to Ⅱ were significantly lower than those in stage Ⅲ to Ⅳ (P ＜ 0.05).The area of serum CA125,CA199 and CEA under the ROC curve was 0.788,0.750 and 0.708,respectively.The boundary points of diagnosis were 50.61 U/ml,36.47 U/ml and 4.32 ng/ml,respectively.The area under the combined diagnosis curve of the serum CA125,CA199 and CEA was 0.832.The sensitivity,specificity and accuracy of the combined detection were higher than that of single index detection and serum combined detection.Conclusions Ultrasound combined with serum CA125,CA199 and CEA levels detection can improve the sensitivity,specificity and accuracy of diagnosis of ovarian benign and malignant tumors,which has certain clinical value.
