Analysis of factors related to perineural invasion in cervical cancer and its relationship with prognosis
10.3760/cma.j.issn.1008-1372.2020.02.006
- VernacularTitle:宫颈癌神经侵袭相关因素及预后分析
- Author:
Chuqi YANG
1
;
Lihong ZHENG
;
Lian'e ZHOU
;
Anxia WAN
;
Shijun WANG
Author Information
1. 首都医科大学宣武医院妇产科
- Keywords:
Uterine cervical neoplasms;
Perineural invasion;
Prognosis;
Factor analysis,statistical
- From:
Journal of Chinese Physician
2020;22(2):184-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between perineural invasion (PNI) and the clinicopathological features of cervical cancer,and to explore its influence on the prognosis of cervical cancer patients.Methods Retrospective analysis the clinical data of 76 patients with early cervical cancer who received radical hysterectomy + pelvic lymphadenectomy ± paraaortic lymphadenectomy from November 2015 to December 2019 in Xuanwu Hospital.The clinicopathological characteristics of the postoperative pathological results of cervical cancer patients were analyzed to explore the related factors of PNI and its influence on prognosis.Results Single factor analysis suggested that the incidence of PNI was related to tumor diameter,depth of stroma invasion,lymph-vascular space invasion,lymph node metastasis and clinical stage (P ＜ 0.05).Multivariate analysis suggested that the infiltration depth of stroma invasion was the risk factor of PNI (P ＜ 0.05).K-M analysis showed that there was no significant difference in disease-free survival and overall survival between PNI positive and PNI negative patients (P ＞ 0.05).Conclusions PNI is related to the depth of interstitial infiltration.PNI has no significant effect on the short-term recurrence rate and short-term survival rate of cervical cancer patients.
