The neural modulation effect of prefrontal cortex and related mechanism in non-pharmacological therapy of chronic pain
10.3760/cma.j.cn371468-20200518-01375
- VernacularTitle:前额叶在慢性疼痛非药物治疗中的神经调控作用及机制
- Author:
Xi LU
1
;
Shu ZHOU
;
Yunlong XIE
;
Xiaoying BI
Author Information
1. 上海长海医院神经内科 200433
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2020;29(9):854-859
- CountryChina
- Language:Chinese
-
Abstract:
Chronic pain is a public health concern of desiderate to be solved, and analgesics is not always successful and may be difficult to tolerate in clinic.Studies have suggested that the development of chronic pain involves alterations in multiple brain regions.Central modulation mechanisms, especially those soliciting the prefrontal cortex and its related brain regions, may play an important role.Non-pharmacological therapies such as transcranial direct current stimulation, transcranial repetitive magnetic stimulation and cognitive behavior therapy have emerged to be effective interventions of great potential for chronic pain in recent years.Hereby the research progress was reviewed on the neural modulation effect of prefrontal cortex in non-pharmacological treatment of chronic pain, focusing on the related changes in brain structure and function, to further explore the underlying mechanism of pain modulation, and provide theoretical basis to optimize non-pharmacological treatment of chronic pain.
