Association study of the BDNF promoter methylation status with panic disorder
10.3760/cma.j.cn371468-20200415-01256
- VernacularTitle:脑源性神经营养因子基因启动子区DNA甲基化与惊恐障碍的关联研究
- Author:
Zhili ZOU
1
;
Yulan HUANG
;
Jinyu WANG
;
Jian QIU
;
Shuya PAN
;
Luyao WANG
;
Bo ZHOU
Author Information
1. 四川省人民医院心身医学中心，成都 610072
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2020;29(9):792-796
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether brain-derived neurotrophic factor (BDNF) promoter methylation status is associated with panic disorder(PD), and then assess the effect of the BDNF gene methylation status on the severity of clinical symptoms in PD.Methods:The methylation levels of the BDNF gene were compared between 111 patients with PD and 130 matched healthy controls using MethylTarget approach.In addition, the panic disorder severity scale(PDSS), Hamilton anxiety rating scale(HAM-A), and Hamilton depression rating scale(HAM-D) were respectively assessed to all subjects.Results:(1)The result showed that 7 CpG regions from the promoter regions of the BDNF gene were sequenced.However, there was no statistically significant differences between cases and controls in terms of BDNF DNA methylation status ( OR=1.087, 95% CI=0.849-1.391, P>0.05). (2)Spearman correlation analysis revealed that the hypermethylation of BDNF gene was significantly associated with the severity of the depressive symptoms in PD patients (all P<0.05). The methylation levels of BDNF gene was not significantly related to the severity of anxiety and panic in PD patients(all P>0.05). Conclusion:No association between BDNF promoter methylation status and panic disorder is found in Chinese Han population, but BDNF promoter methylation status may be related to the severity of depressive symptoms in patient with panic disorder.
