Multiple mediating effects of depression and physical diseases on the influence of cognitive function in community mild cognitive impairment patients
10.3760/cma.j.cn371468-20191216-00917
- VernacularTitle:抑郁和躯体疾病对社区轻度认知障碍患者认知功能影响的双重中介效应
- Author:
Xiaoshen LIU
1
;
Chen ZHANG
;
Lina WANG
;
Xueting ZHEN
;
Jie WANG
;
Chenxi GE
Author Information
1. 湖州师范学院医学院，湖州 313000
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2020;29(9):820-826
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the action path and the potential mediating effects of depression and physical diseases on the influencing factors of mild cognitive impairment(MCI) in community, and provide the theoretical basis for the construction of the strategy of cognitive regulation.Methods:A convenient sample survey was conducted on 252 mild cognitive impairment patients in the community undergoing screening using the general information questionnaire, Montreal cognitive assessment scale(MoCA) and geriatric depression scale(GDS-15)from January 2018 to June 2019. SPSS 22.0 and AMOS 22.0 softwares were used to conduct descriptive analysis, correlation analysis, structural equation model and confirmatory factor analysis.Results:The score of MoCA was 19.66±3.90 for all MCI patients. There were significant correlations among age, education, social frequency, physical exercise frequency and depression degree, the number of physical disease and MoCA( r=-0.440-0.487, P<0.01). The structural equation model fits well(χ 2/ df=2.476, TLI=0.885, CFI=0.916, GFI=0.919, AGFI=0.871, RMSEA=0.077). Mediation modeling analysis showed that age, education, social frequency physical exereise frequency had a direct effect on cognitive function(effect value was -0.183, 0.458, 0.237, 0.174, P<0.01). There were partly mediating effect of the number of physical disease between age, education, physical exercise frequency and cognitive function(effect value was -0.106, 0.078, 0.075, P<0.01), and there were partly mediating effect of depression degree between age, social frequency, physical exercise frequency and cognitive function(effect value was -0.075, 0.080, 0.050, P<0.01), and there were chain mediating effect of the number of physical disease-depression degree between age, education, physical exercise(effect value was -0.028, 0.031, 0.019, P<0.01). Conclusion:The cognitive management of MCI among community should focus on the elderly, low education level groups.In the implementation of exercise intervention to improve cognitive function of health management strategy, while to strengthen the effective management of physical diseases and negative emotion evaluation and dredging, to increase the effect of exercise intervention on cognitive function improvement.
